Allele Frequencies: Changing

John Stanton-Geddes; johnsg@uvm.edu
25 October 2013

www.johnstantongeddes.org

Evolutionary Processes

These forces will change allele frequencies in a population

  • Mutation
  • Migration
  • Non-random Mating
  • Genetic Drift
  • Natural Selection

Mutation

  • source of all genetic variation
  • due to mistakes in DNA replication


What is the mutation rate for humans?

Mutation

mutation rate

Conrad et al. (2011) doi:10.1038/ng.862

Migration

Individuals with specific genotypes move in or out of a population

Source-sink population dynamics