Translation II: from polypeptides to proteins

John Stanton-Geddes
15 November 2013

Overview

Part 1) How do polypeptides become proteins?

  • post-translational modification
  • polypeptide coils and folds
  • assembly with other polypeptides


Part 2) Solving a medical mystery

Review: protein synthesis

17.19

The mRNA sequence

5` CUAGACUAC 3'

encodes the polypeptide

Leu-Asp-Tyr

If the first C is deleted, what new amino acid will be produced?

  1. Asp-Tyr
  2. Leu-Asp
  3. Leu-Asp-Tyr
  4. Tyr
  5. Nothing

17.05

A medical mystery: solved!

Prions

Bovine spongiform encephalitis